A chemically induced lymphosarcoma line (LSBM-1) of C57BL/10 (H-2b) origin lacks detectable TATA and is scarcely immunogenic for H-2-incompatible congenic recipients. New antigenic specificities, defined as drug-mediated tumor antigen(s) (DMTA) were found in a subline (LBD-1) obtained by in vivo treatment of LSBM-1 with the anti-neoplastic agent dimethyl-1-triazeno-imidazole-carboxamide (DTIC) over several transplant generations. It was concluded that the presence of detectable TATA is not a prerequisite for the induction of new antigenic specificities (DMTA).
Appearance of strong transplantation antigens in non-immunogenic lymphoma following drug-treatment in vivo / M.C. Fioretti, L. Romani, A. Bonmassar, D. Taramelli. - In: JOURNAL OF IMMUNOPHARMACOLOGY. - ISSN 0163-0571. - 2:2(1980), pp. 189-212. [10.3109/08923978009026397]
Appearance of strong transplantation antigens in non-immunogenic lymphoma following drug-treatment in vivo
D. TaramelliUltimo
1980
Abstract
A chemically induced lymphosarcoma line (LSBM-1) of C57BL/10 (H-2b) origin lacks detectable TATA and is scarcely immunogenic for H-2-incompatible congenic recipients. New antigenic specificities, defined as drug-mediated tumor antigen(s) (DMTA) were found in a subline (LBD-1) obtained by in vivo treatment of LSBM-1 with the anti-neoplastic agent dimethyl-1-triazeno-imidazole-carboxamide (DTIC) over several transplant generations. It was concluded that the presence of detectable TATA is not a prerequisite for the induction of new antigenic specificities (DMTA).
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