Triadimefon and triadimenol, fungicides used in agriculture, are suspected of producing cramofacial malformations. As the results of FETAX analysis showed that Triadimefon was highly teratogenic, we studied the action of these triazoles on the development of the branchial apparatus in Xenopus, using early molecular markers and analysis of the cartilaginous-muscular elements of tadpoles. Teratogenic effects were observed, after exposure at the neurula stage, at the level of cartilages and muscles of the 1st and 2nd branchial arches. By in situ hybridization, we observed that in exposed specimens the territories of the branchial arches are perturbed. From these results, we considered the craniofacial malformations related to the influence of triazoles on the differentiation of branchial arches. Comparing the anomalies caused by triazoles and by retinoic acid (RA) led us to the conclusion that triazoles can affect endogenous RA content, as has been shown for mammals. (c) 2005 Elsevier B.V. All rights reserved.
Teratogenic effects of two antifungal triazoles, triadimefon and triadimenol, on Xenopus laevis development : Craniofacial defects / S. Groppelli, R. Pennati, F. De Bernardi, E. Menegola, E. Giavini, C. Sotgia. - In: AQUATIC TOXICOLOGY. - ISSN 0166-445X. - 73:4(2005), pp. 370-381.
|Titolo:||Teratogenic effects of two antifungal triazoles, triadimefon and triadimenol, on Xenopus laevis development : Craniofacial defects|
GROPPELLI, SILVIA RENATA (Primo)
PENNATI, ROBERTA (Secondo)
GIAVINI, ERMINIO (Penultimo)
SOTGIA, CRISTINA (Ultimo)
|Parole Chiave:||FETAX; retinoic acid; jaw defects; in situ hybridization; goosecoid; Xl-fli|
|Settore Scientifico Disciplinare:||Settore BIO/05 - Zoologia|
Settore BIO/06 - Anatomia Comparata e Citologia
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.aquatox.2005.04.004|
|Appare nelle tipologie:||01 - Articolo su periodico|