The expression of class I and class II HLA antigens has been studied on primary and metastatic human melanomas, and on cell clones derived from the latter. A panel of monoclonal antibodies and flow cytofluorometric analysis were used to evaluate the presence of HLA-A, B, C and -DR, DQ antigens on freshly isolated tumour cells. HLA class I antigens were present on 91% and 93% of primary and metastatic tumours, respectively. Sixty per cent of primary and 50% of metastatic melanomas expressed HLA-DR antigens, whereas 38% and 21% of cases were positive for HLA-DQ. A marked heterogeneity was evident among primary and metastatic lesions for expression of class I and II antigens. Similar findings were obtained by analysing the phenotype of melanoma clones which indicates that a marked antigenic heterogeneity for class I and II HLA antigens occurs even among clones isolated from short-term cultures of metastatic melanomas.
Phenotypic heterogeneity of HLA products on human melanoma cells / G. Parmiani, D. Taramelli, A. Anichini, S. Andreola, N. Cascinelli, G. Fossati. - In: JOURNAL OF IMMUNOGENETICS. - ISSN 0305-1811. - 13:2-3(1986), pp. 235-240.
|Titolo:||Phenotypic heterogeneity of HLA products on human melanoma cells|
TARAMELLI, DONATELLA (Secondo)
|Parole Chiave:||antibodies, monoclonal; clone cells; HLA antigens; HLA-DQ antigens; HLA-DR antigens; histocompatibility antigens class II; humans; melanoma; phenotype|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||1986|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1744-313X.1986.tb01106.x|
|Appare nelle tipologie:||01 - Articolo su periodico|