A novel system for remote monitoring of metabolism in an animal model is proposed in this paper. The system is obtained by integrating bio-nano-sensors to detect single-metabolites, an electrochemical front-end made with off-the-shelf components, a radio frequency communication sub-system, and an antenna of new design. The system has been calibrated and tested for continuous monitoring of four different metabolites: glucose, lactate, glutamate, and adenosine triphosphate. Tests using animal models (mice) have been conducted to investigate tissue inflammation induced by the implanted bio-nano-sensors. These tests confirm that our system is suitable and reliable for remote monitoring of single-metabolites in experiments with animal models.
Remote system for monitoring animal models with single-metabolite bio-nano-sensors / S. Carrara, L. Bolomey, C. Boero, A. Cavallini, E. Meurville, G. De Micheli, T.R. Jost, M. Proietti, F. Grassi. - In: IEEE SENSORS JOURNAL. - ISSN 1530-437X. - 13:3(2013 Mar), pp. 6374200.1018-6374200.1024. [10.1109/JSEN.2012.2231670]
Remote system for monitoring animal models with single-metabolite bio-nano-sensors
M. ProiettiPenultimo
;F. GrassiUltimo
2013
Abstract
A novel system for remote monitoring of metabolism in an animal model is proposed in this paper. The system is obtained by integrating bio-nano-sensors to detect single-metabolites, an electrochemical front-end made with off-the-shelf components, a radio frequency communication sub-system, and an antenna of new design. The system has been calibrated and tested for continuous monitoring of four different metabolites: glucose, lactate, glutamate, and adenosine triphosphate. Tests using animal models (mice) have been conducted to investigate tissue inflammation induced by the implanted bio-nano-sensors. These tests confirm that our system is suitable and reliable for remote monitoring of single-metabolites in experiments with animal models.Pubblicazioni consigliate
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