Tumor necrosis factor-alfa (TNF-α) is a cytokine that plays a central role in the pathogenesis of psoriasis; the treatment with anti–TNF-α agents, as etanercept, has proved to be highly effective although its mechanism on the overall epidermal cytoarchitecture has still to be elucidated. The aim of the present study was to investigate if etanercept treatment of psoriatic patients could affect the expression of the main biomarkers of keratinocyte terminal differentiation (TD) along with epithelial cell proliferation.
Anti-tumor necrosis factor-alfa and psoriasis : new insights on keratinocyte differentiation markers / F. Prignano, A. Gualerzi, E. Donetti, F. Ricceri, L. Tripo, L. Pescitelli, M. Bedoni. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - 68:4, supplement 1(2013 Apr), pp. AB193-AB193. (Intervento presentato al 71. convegno Annual meeting of the American academy of dermatology (AAD) tenutosi a Miami Beach nel 2013) [10.1016/j.jaad.2012.12.797].
Anti-tumor necrosis factor-alfa and psoriasis : new insights on keratinocyte differentiation markers
A. Gualerzi;E. Donetti;M. Bedoni
2013
Abstract
Tumor necrosis factor-alfa (TNF-α) is a cytokine that plays a central role in the pathogenesis of psoriasis; the treatment with anti–TNF-α agents, as etanercept, has proved to be highly effective although its mechanism on the overall epidermal cytoarchitecture has still to be elucidated. The aim of the present study was to investigate if etanercept treatment of psoriatic patients could affect the expression of the main biomarkers of keratinocyte terminal differentiation (TD) along with epithelial cell proliferation.
| File | Dimensione | Formato | |
|---|---|---|---|
|
antitumor-necrosis-factoralfa-and-psoriasis-new-insights-on-kera-2013.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
48.27 kB
Formato
Adobe PDF
|
48.27 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
