Several cutaneous inflammatory diseases and their clinical phenotypes are recapitulated in animal models of skin disease. However, the identification of shared pathways for disease progression is limited by the ability to delineate the complex biochemical processes fundamental for development of the disease. Identifying common signaling pathways that contribute to cutaneous inflammation and immune function will facilitate better scientific and therapeutic strategies to span a variety of inflammatory skin diseases. Aberrant antimicrobial peptide (AMP) expression and activity is one mechanism behind the development and severity of several inflammatory skin diseases and directly influences the susceptibility of skin to microbial infections. Our studies have recently exposed a newly identified pathway for negative regulation of AMPs in the skin by the cholinergic anti-inflammatory pathway via acetylcholine (ACh). The role of ACh in AMP regulation of immune and permeability barrier function in keratinocytes is reviewed, and the importance for a better comprehension of cutaneous disease progression by cholinergic signaling is discussed.
Anti-TNF-alpha molecules establish a more differentiated phenotype in psoriatic epidermis / L. Pescitelli, F. Prignano, L. Tripo, F. Ricceri, E. Donetti, A. Gualerzi, M. Bedoni. - In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - ISSN 0022-202X. - 132:s2(2012), pp. 155.28-155.28. ((Intervento presentato al 42. convegno Annual meeting of the European society for dermatological research (ESDR) tenutosi a Venice nel 2012.
|Titolo:||Anti-TNF-alpha molecules establish a more differentiated phenotype in psoriatic epidermis|
|Settore Scientifico Disciplinare:||Settore BIO/16 - Anatomia Umana|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/jid.2011.264|
|Appare nelle tipologie:||01 - Articolo su periodico|