Evidence available from nutritional epidemiology has indicated an inverse association between regular consumption of fruits and vegetables and the risk of developing certain types of cancer. In turn, preclinical studies have attributed the health-promoting effects of plant foods to some groups of phytochemicals, by virtue of their many biological activities. In this survey, we briefly examine the chemopreventive potential of flavonoids and flavonoid-rich foods in human oral carcinogenesis. Despite the paucity of data from clinical trials and epidemiological studies, in comparison to in vitro/in vivo investigations, a high level of evidence has been reported for epigallocatechin gallate (EGCG) and anthocyanins. These flavonoids, abundant in green tea and black raspberries, respectively, represent promising chemopreventive agents in human oral cancer.
Chemopreventive potential of flavonoids in oral squamous cell carcinoma in human studies / M. Iriti, E.M. Varoni. - In: NUTRIENTS. - ISSN 2072-6643. - 5:7(2013), pp. 2564-2576.
|Titolo:||Chemopreventive potential of flavonoids in oral squamous cell carcinoma in human studies|
IRITI, MARCELLO (Corresponding)
VARONI, ELENA MARIA (Ultimo)
|Parole Chiave:||anthocyanins; black raspberry; nanochemoprevention; nanoparticles; oral cancer; polyphenols; tea; transmucosal oral delivery; administration, mucosal; anticarcinogenic agents; catechin; chemoprevention; drug delivery systems; flavonoids; fruit; humans; mouth neoplasms; nanoparticles; polyphenols; randomized controlled trials as topic; tea; food science|
|Settore Scientifico Disciplinare:||Settore MED/28 - Malattie Odontostomatologiche|
Settore BIO/04 - Fisiologia Vegetale
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/nu5072564|
|Appare nelle tipologie:||01 - Articolo su periodico|