Triazole fungicides are used in medicine as well as in agricultural treatment of mycoses. The pharmacological mechanism is related to the inhibition of CYP enzymes involved in the formation of the fungal walls. A similar inhibition of human CYP enzymes has been suggested as the cause of triazole side effects in humans. An importent role of some CYP isoforms (CYP26 isoforms) expressed during mammalian development is the catabolism of retinoic acid, a known morphogen in vertebrates and invertebrates. The adverse effects on morphogenesis, observed after exposure of mammalian, anfibian and ascidiacea, are compared to the reported effects of triazole in humans. The possible pathogenic pathway in triazole-related teratogenesis is discussed on the basis of different experimental approaches.

Postulated pathogenic pathway in triazole fungicide induced dysmorphogenic effects / E. Menegola, M.L. Broccia, F. Di Renzo, E. Giavini. - In: REPRODUCTIVE TOXICOLOGY. - ISSN 0890-6238. - 22:2(2006), pp. 186-195.

Postulated pathogenic pathway in triazole fungicide induced dysmorphogenic effects

E. Menegola
Primo
;
M.L. Broccia
Secondo
;
F. Di Renzo
Penultimo
;
E. Giavini
Ultimo
2006

Abstract

Triazole fungicides are used in medicine as well as in agricultural treatment of mycoses. The pharmacological mechanism is related to the inhibition of CYP enzymes involved in the formation of the fungal walls. A similar inhibition of human CYP enzymes has been suggested as the cause of triazole side effects in humans. An importent role of some CYP isoforms (CYP26 isoforms) expressed during mammalian development is the catabolism of retinoic acid, a known morphogen in vertebrates and invertebrates. The adverse effects on morphogenesis, observed after exposure of mammalian, anfibian and ascidiacea, are compared to the reported effects of triazole in humans. The possible pathogenic pathway in triazole-related teratogenesis is discussed on the basis of different experimental approaches.
Branchial arches; Cranio-facial; CYP26; Embryo; Fungicides; Malformation; Retinoic acid; Triazole
Settore BIO/06 - Anatomia Comparata e Citologia
2006
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/24449
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