The construction of well-defined nanostructures from the self-assembly of small organic molecules has gained increasing attention in the last decade . The use of peptides, in particular, gives access to different ordered and, in some case, intricate morphologies . For this high structural variability, peptide-based supramolecular assemblies are of valuable interest in biological systems as transmembrane pores models, ion channels mimics, and as drug delivery vehicles . On the other hand, one drawback of using peptides for biomedical applications is their high susceptibility toward proteases and their short half-lives. The use of unnatural amino acids, such as alpha-alpha-disubstituted, beta-, and D-amino acids, is a profitable strategy to overcome these issues [3c, 4].
Self-assembly of dipeptide nanotubes constituted by (S,S) beta-diarylaminoacid and (L)-alanine, as putative drug delivery system / S. Pellegrino, A. Bonetti, F. Meneghetti, M.L. Gelmi, M. Reiches - In: Nanomedicine: pharmacokinetic challenges, targeting and clinical outcomes[s.l] : CRS Italy Chapter, 2014 Nov 07. (( convegno CRS Workshop tenutosi a Firenze nel 2014.
|Titolo:||Self-assembly of dipeptide nanotubes constituted by (S,S) beta-diarylaminoacid and (L)-alanine, as putative drug delivery system|
PELLEGRINO, SARA (Primo)
BONETTI, ANDREA (Secondo)
GELMI, MARIA LUISA (Penultimo)
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Progetto:||Piano Sviluppo Unimi - LINEA B - DOTAZIONE ANNUALE PER ATTIVITA' ISTITUZIONALI|
|Data di pubblicazione:||7-nov-2014|
|Tipologia:||Book Part (author)|
|Appare nelle tipologie:||03 - Contributo in volume|