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IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishWe investigated the effects of simvastatin treatment on the expression of IL-1beta and MCP-1, the activity of NF-kB, and the signaling pathways related to NF-kB activation in a rat model of permanent middle cerebral artery occlusion (pMCAO). IL-1beta and MCPA expression, determined using RT-PCR, was enhanced by pMCAO; this effect was inhibited by the administration of simvastatin before ischemia. Pre-treatment with simvastatin abolished the ischemia-induced activation of NF-kB observed in vehicle-treated animals. The evaluation of signal transduction pathways, including extracellular signal-regulated kinase (ERK1/2), SAPK/JNK 46/54 and p38, indicated that only ERK1/2 phosphorylation was enhanced by ischemia, and this activation was prevented by simvastatin. ERK1/2-inhibitor, U0126, reduced brain ischemia but not cytokine induction. These results provide evidence that the HMG-CoA reductase inhibitor induces its effect in the protection of ischemic brain damage with a more complex mechanism which also involve anti-inflammatory properties rather than simple inhibition of ERK1/2 signaling pathway. (c) 2005 Elsevier Inc. All rights reserved.
| Titolo: | Activation of NF-kB and ERK1/2 after permanent focal ischemia is abolished by simvastatin treatment |
| Autori: | SIRONI, LUIGI (Primo) BANFI, CRISTINA (Secondo) TREMOLI, ELENA (Penultimo) |
| Parole Chiave: | statin; inflammation; cerebral ischemia; permanent middle; cerebral artery occlusion; transcription factor; MAP kinase; rat |
| Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia |
| Data di pubblicazione: | 2006 |
| Rivista: | |
| URL: | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNK-4J7B0W4-5&_user=1080510&_coverDate=05%2F31%2F2006&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000051355&_version=1&_urlVersion=0&_userid=1080510&md5=504aa6848d0b3f2f989f78974c016a02 |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.nbd.2005.12.004 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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