The definitive fate of peripherally injected PKH26 labelled bone marrow mononuclear cells expressing the CD34+ antigen following experimental myocardial cryodamage in rats(n=10)has been examined by direct visualization on photoconverted light and electron microscopy images. One week after injection in each rat of about 150,000CD34+ cells early stage PKH26+ vascular were localized in the infarcted areas, suggesting that a potential benefit of this therapeutic approach consists in the regeneration of the vasculature.
Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage / M.M. Ciulla, S. Ferrero, U. Gianelli, R. Paliotti, F. Magrini, P. Braidotti. - In: MICRON. - ISSN 0968-4328. - 38:3(2007), pp. 321-322. [10.1016/j.micron.2006.08.007]
Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in experimental myocardial damage
M.M. CiullaPrimo
;S. FerreroSecondo
;U. Gianelli;R. Paliotti;F. MagriniPenultimo
;P. BraidottiUltimo
2007
Abstract
The definitive fate of peripherally injected PKH26 labelled bone marrow mononuclear cells expressing the CD34+ antigen following experimental myocardial cryodamage in rats(n=10)has been examined by direct visualization on photoconverted light and electron microscopy images. One week after injection in each rat of about 150,000CD34+ cells early stage PKH26+ vascular were localized in the infarcted areas, suggesting that a potential benefit of this therapeutic approach consists in the regeneration of the vasculature.
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