The discovery of opioid receptors expression on immune cells has originated a large research activity on the possible modulation by opioid drugs of immune system responses. In the present chapter we describe an easy methodology useful to obtain information about the potential immunomodulatory activity of opioid drugs. An in vivo treatment schedule is used, and macrophages are studied for their ability to release different cytokines.
Evaluation of murine macrophage cytokine production after in vivo morphine treatment / S. Franchi, M. Castelli, S. Moretti, A. Panerai, P. Sacerdote (METHODS IN MOLECULAR BIOLOGY). - In: Opioid receptors / [a cura di] S.Spampinato. - [s.l] : Springer, 2015. - pp. 253-261 [10.1007/978-1-4939-1708-2_21]
Evaluation of murine macrophage cytokine production after in vivo morphine treatment.
S. FranchiPrimo
;M. CastelliSecondo
;S. Moretti;A. PaneraiPenultimo
;P. Sacerdote
2015
Abstract
The discovery of opioid receptors expression on immune cells has originated a large research activity on the possible modulation by opioid drugs of immune system responses. In the present chapter we describe an easy methodology useful to obtain information about the potential immunomodulatory activity of opioid drugs. An in vivo treatment schedule is used, and macrophages are studied for their ability to release different cytokines.
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