The authors assessed MATILDE chemotherapy followed by response-tailored radiation therapy in 41 patients aged 70 years or younger with primary CNS lymphoma in a Phase II trial. With response rates of 76% after MATILDE and 83% after chemotherapy with or without radiation therapy, this was an active strategy, particularly in low- to intermediate-risk patients (International Extranodal Lymphoma Study Group [IELSG] score). Myelosuppression was the dose-limiting toxicity, with 9.5% of lethal complications. After a median follow-up of 49 months, a plateau in the survival curve (5-year overall survival: 41 +/- 7%) was obtained.
|Titolo:||MATILDE regimen followed by radiotherapy is an active strategy against primary CNS lymphomas|
|Autori interni:||BALDINI, LUCA|
|Data di pubblicazione:||2006|
|Digital Object Identifier (DOI):||10.1212/01.wnl.0000210464.94122.e1|
|Appare nelle tipologie:||01 - Articolo su periodico|