The synthesis of multifunctional organic catalysts, easily obtained by the condensation of (S)-proline with 1,1'-binaphthyl-2,2'-diamine is reported. These C-2 as well as C, symmetric prolinamides were shown to be able to promote the direct aldol condensation between acetone, methoxyacetone or cyclohexanone and different aldehydes in very good yields and high enantio selectivities.

A multifunctional proline-based organic catalyst for enantioselective aldol reactions / S. Guizzetti, M. Benaglia, L. Pignataro, A. Puglisi. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 17:19(2006), pp. 2754-2760. [10.1016/j.tetasy.2006.10.018]

A multifunctional proline-based organic catalyst for enantioselective aldol reactions

GUIZZETTI, STEFANIA;M. Benaglia;L. Pignataro;A. Puglisi
2006

Abstract

The synthesis of multifunctional organic catalysts, easily obtained by the condensation of (S)-proline with 1,1'-binaphthyl-2,2'-diamine is reported. These C-2 as well as C, symmetric prolinamides were shown to be able to promote the direct aldol condensation between acetone, methoxyacetone or cyclohexanone and different aldehydes in very good yields and high enantio selectivities.
binam-prolinamides; aldehydes; acid; organocatalysts; design; condensation; derivatives; mannich
Settore CHIM/06 - Chimica Organica
TETRAHEDRON-ASYMMETRY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/24101
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