The effects of electron beam or γ-irradiation on technological performances (capsule hardness, expressed as deforming work and dissolution time) of empty 2-shell capsules made of gelatin or hydroxypropylmethylcellulose (HPMC) were studied. Capsule structural changes induced by radiation treatment were investigated by capillary viscometry and atomic force microscopy (AFM). The capsules were irradiated in the air at 5, 15, and 25 kGy. The deforming work of nonirradiated HPMC capsules (0.06 ± 0.01 J) was lower than that of gelatin capsules (0.10 ± 0.01 J). The dissolution time of the HPMC capsules (414 ± 33 seconds) was slightly higher than that determined for gelatin hard capsules (288 ± 19 seconds). The hardness and dissolution time of gelatin and HPMC capsules were not significantly influenced by the irradiation type and the applied irradiation dose. As the viscometry analyses are concerned, irradiation caused a reduction of the intrinsic viscosity and water and dimethyl sulfoxide solvent power in both the cases. AFM analysis showed that the radiation treatment did not appreciably affect the surface roughness of the samples nor induce structural changes on capsule surface. However, measurements of force-distance curves pointed out a qualitative parameter for the identification of the irradiated capsules. On the bases of these preliminary results, empty gelatin or HPMC hard capsules can be sanitized/sterilized by ionizing radiation

Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules / F. Cilurzo, F. Selmin, P. Minghetti, L. Montanari, C. Lenardi, F. Orsini, G. Poletti. - In: AAPS PHARMSCITECH. - ISSN 1530-9932. - 6:4(2005 Jan 12), pp. 73.E586-73.E593.

Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules

F. Cilurzo;F. Selmin;P. Minghetti;L. Montanari;C. Lenardi;F. Orsini;G. Poletti
2005

Abstract

The effects of electron beam or γ-irradiation on technological performances (capsule hardness, expressed as deforming work and dissolution time) of empty 2-shell capsules made of gelatin or hydroxypropylmethylcellulose (HPMC) were studied. Capsule structural changes induced by radiation treatment were investigated by capillary viscometry and atomic force microscopy (AFM). The capsules were irradiated in the air at 5, 15, and 25 kGy. The deforming work of nonirradiated HPMC capsules (0.06 ± 0.01 J) was lower than that of gelatin capsules (0.10 ± 0.01 J). The dissolution time of the HPMC capsules (414 ± 33 seconds) was slightly higher than that determined for gelatin hard capsules (288 ± 19 seconds). The hardness and dissolution time of gelatin and HPMC capsules were not significantly influenced by the irradiation type and the applied irradiation dose. As the viscometry analyses are concerned, irradiation caused a reduction of the intrinsic viscosity and water and dimethyl sulfoxide solvent power in both the cases. AFM analysis showed that the radiation treatment did not appreciably affect the surface roughness of the samples nor induce structural changes on capsule surface. However, measurements of force-distance curves pointed out a qualitative parameter for the identification of the irradiated capsules. On the bases of these preliminary results, empty gelatin or HPMC hard capsules can be sanitized/sterilized by ionizing radiation
AFM; Electron beam irradiation; Gamma irradiation; Gelatin capsule; HPMC capsule
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Settore FIS/01 - Fisica Sperimentale
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Settore FIS/01 - Fisica Sperimentale
12-gen-2005
http://www.aapspharmscitech.org/view.asp?art=pt060473
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/24082
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