A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13–25), structurally related to model compound 5 (2-[(4-aminophenyl)-(4-methylsemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester), were synthesized and tested as anticonvulsant agents in DBA/2 mice against sound-induced seizures. The new compounds possess anticonvulsant properties lower than those of prototype 5 but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist
Design of 1-substituted 2-arylmethyl-4,5-methylene-dioxybenzene derivatives as antiseizure agents / Nicola Micale, Giovambattista De Sarro, Guido Ferreri, Maria Zappalá, Silvana Grasso, Giulia Puia, Carlo De Micheli. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 12:13(2004 Jul 01), pp. 3703-3709.
Titolo: | Design of 1-substituted 2-arylmethyl-4,5-methylene-dioxybenzene derivatives as antiseizure agents |
Autori: | |
Settore Scientifico Disciplinare: | Settore CHIM/08 - Chimica Farmaceutica |
Data di pubblicazione: | 1-lug-2004 |
Rivista: | |
URL: | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF8-4CDJ9YR-5&_user=1080510&_coverDate=07%2F01%2F2004&_alid=553195718&_rdoc=1&_fmt=full&_orig=search&_cdi=5220&_sort=d&_docanchor=&view=c&_ct=1&_acct=C000051355&_version=1&_urlVersion=0&_userid=1080510&md5=60ae9da74834daaf2f5e89d2ec4ef3a1 |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.bmc.2004.04.015 |
Appare nelle tipologie: | 01 - Articolo su periodico |