The vitamin K-dependent proteins (VKDPs) matrix Gla protein and osteocalcin protect from cardiovascular calcifications and bone fractures. A vitamin K recycling system maintains sufficient vitamin K levels for activation of VKDPs through γ-glutamyl carboxylase (GGCX). Kaesler et al. demonstrate that uremia per se can interfere with GGCX activity, contributing to vitamin K deficiency in chronic kidney disease and opening the path to the clinical use of vitamin K, currently tested in randomized trials.
Vitamin K and cardiovascular calcification in CKD : is patient supplementation on the horizon? / M. Gallieni, M. Fusaro. - In: KIDNEY INTERNATIONAL. - ISSN 0085-2538. - 86:2(2014 Aug), pp. 232-234.
Vitamin K and cardiovascular calcification in CKD : is patient supplementation on the horizon?
M. GallieniPrimo
;
2014
Abstract
The vitamin K-dependent proteins (VKDPs) matrix Gla protein and osteocalcin protect from cardiovascular calcifications and bone fractures. A vitamin K recycling system maintains sufficient vitamin K levels for activation of VKDPs through γ-glutamyl carboxylase (GGCX). Kaesler et al. demonstrate that uremia per se can interfere with GGCX activity, contributing to vitamin K deficiency in chronic kidney disease and opening the path to the clinical use of vitamin K, currently tested in randomized trials.File | Dimensione | Formato | |
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