Objectives: To identify patterns of variation in breast cancer mortality in Europe (1980-2010), using a model-based approach. Methods: Mortality data were obtained from the World Health Organization database and mixed models were used to describe the time trends in the age-standardized mortality rates (ASMR). Model-based clustering was used to identify clusters of countries with homogeneous variation in ASMR. Results: Three patterns were identified. Patterns 1 and 2 are characterized by stable or slightly increasing trends in ASMR in the first half of the period analysed, and a clear decline is observed thereafter; in pattern 1 the median of the ASMR is higher, and the highest rates were achieved sooner. Pattern 3 is characterised by a rapid increase in mortality until 1999, declining slowly thereafter. Conclusion: This study provides a general model for the description and interpretation of the variation in breast cancer mortality in Europe, based in three main patterns. © 2013 Elsevier Ltd.
|Titolo:||Patterns of breast cancer mortality trends in Europe|
LA VECCHIA, CARLO VITANTONIO BATTISTA (Penultimo)
|Parole Chiave:||Breast neoplasms; Cluster analysis; Early detection of cancer; Mortality|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||10.1016/j.breast.2013.02.007|
|Appare nelle tipologie:||01 - Articolo su periodico|