In a previous study, dogs experimentally infected with Dirofilaria immitis were treated with either ivermectin or doxycycline or a combination of both. The adulticide effect was significantly higher in the dogs treated with both drugs and was similar to that observed in dogs treated with melarsomine hydrochloride. In the present study, lung tissue samples from these dogs were evaluated for the presence of T regulatory (Foxp3+) cells by immunohistochemistry. Cells were enumerated for each dog in the four groups and compared with untreated controls. There was a significantly lower number of Treg cells in those dogs treated with a combination of both drugs when compared either to the control group or to the other groups treated with either drug alone or with melarsomine. These results suggest that successful adulticide effects of doxycycline and ivermectin are associated with a decrease in immune regulation towards the parasite.

The adulticide effect of a combination of doxycycline and ivermectin in Dirofilaria immitis-experimentally infected dogs is associated with reduction in local T regulatory cell populations / B. Passeri, A. Vismarra, G. Cricri, C. Bazzocchi, L. Kramer, C. Bacci. - In: VETERINARY PARASITOLOGY. - ISSN 0304-4017. - 205:1-2(2014 Sep 15), pp. 208-210. [10.1016/j.vetpar.2014.06.018]

The adulticide effect of a combination of doxycycline and ivermectin in Dirofilaria immitis-experimentally infected dogs is associated with reduction in local T regulatory cell populations

G. Cricri;C. Bazzocchi;
2014

Abstract

In a previous study, dogs experimentally infected with Dirofilaria immitis were treated with either ivermectin or doxycycline or a combination of both. The adulticide effect was significantly higher in the dogs treated with both drugs and was similar to that observed in dogs treated with melarsomine hydrochloride. In the present study, lung tissue samples from these dogs were evaluated for the presence of T regulatory (Foxp3+) cells by immunohistochemistry. Cells were enumerated for each dog in the four groups and compared with untreated controls. There was a significantly lower number of Treg cells in those dogs treated with a combination of both drugs when compared either to the control group or to the other groups treated with either drug alone or with melarsomine. These results suggest that successful adulticide effects of doxycycline and ivermectin are associated with a decrease in immune regulation towards the parasite.
Dirofilaria immitis ; Immunohistochemistry ; T regulatory cells
Settore VET/06 - Parassitologia e Malattie Parassitarie degli Animali
15-set-2014
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0304401714003550-main.pdf

accesso riservato

Descrizione: ArticoloBazzocchi2014
Tipologia: Publisher's version/PDF
Dimensione 299.32 kB
Formato Adobe PDF
299.32 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/239610
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 4
social impact