We report a case of disseminated microsporidiosis in an Italian woman with AIDS. This study was done retrospectively using formalin-fixed, paraffin-embedded tissue specimens obtained at autopsy. Microsporidia spores were found in the necrotic lesions of the liver, kidney, and adrenal gland and in ovary, brain, heart, spleen, lung, and lymph nodes. The infecting agent was identified as belonging to the genus Encephalitozoon based on transmission electron microscopy and indirect immunofluorescence. Additional molecular studies, including sequence of the rDNA internal transcribed spacer region, identified the agent as E. cuniculi, Genotype III. We believe that this is the first report of a human case of disseminated microsporidial infection involving the ovary.
Disseminated microsporidiosis caused by Encephalitozoon cuniculi III (dog type) in an Italian AIDS patient: a retrospective study / A. Tosoni, M. Nebuloni, A. Ferri, S. Bonetto, S. Antinori, M. Scaglia, L. Xiao, H. Moura, G.S. Visvesvara, L. Vago, G. Costanzi. - In: MODERN PATHOLOGY. - ISSN 0893-3952. - 15:5(2002), pp. 577-583.
|Titolo:||Disseminated microsporidiosis caused by Encephalitozoon cuniculi III (dog type) in an Italian AIDS patient: a retrospective study|
NEBULONI, MANUELA (Secondo)
COSTANZI, GIULIO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/08 - Anatomia Patologica|
Settore MED/17 - Malattie Infettive
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||2002|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/modpathol.3880566|
|Appare nelle tipologie:||01 - Articolo su periodico|