An easy entry to uncommon 2-propargylbenzaldehydes was developed. 2-propargylbenzaldehydes demonstrated to be suitable building blocks for the synthesis of 3-benzyl isoquinolines by microwave promoted domino imination/cycloisomerisation in the presence of ammonium acetate. A small library of 3-benzyl isoquinolines was obtained in good yields under mild reaction conditions. Two alternative plausible reaction mechanisms are proposed.
|Titolo:||Synthesis of 3-benzylisoquinolines by domino imination/cycloisomerisation of 2-propargylbenzaldehydes|
|Parole Chiave:||Isoquinolines; Alkynes; Nitrogen heterocycles; Domino reactions; Microwaves|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||28-ott-2014|
|Digital Object Identifier (DOI):||10.1039/C4OB01583E|
|Appare nelle tipologie:||01 - Articolo su periodico|