Specifications for cetyltrimethylammonium (CTA) naproxenate (naprocet), the active ingredient of pharmaceutical liquid preparations used as antiseptic−antinflammatory detergents, fix severe limits to the presence of residual inorganic counteranion deriving from the starting CTA salt. A new simple procedure, which avoids ionic exchange chromatography and utilizes CTAHSO4 in place of CTABr and CTACl, exploits the quantitative precipitation of K2SO4 from methanol to yield naprocet in line with such specification requirements.
Simple process for the preparation of cetyltrimethylammonium naproxenate (naprocet) / C. Bolchi, E. Valoti, L. Fumagalli, P. Ruggeri, V. Straniero, M. Pallavicini. - In: ORGANIC PROCESS RESEARCH & DEVELOPMENT. - ISSN 1083-6160. - 18:8(2014 Aug), pp. 976-979. [10.1021/op500175v]
Simple process for the preparation of cetyltrimethylammonium naproxenate (naprocet)
C. Bolchi;E. Valoti;L. Fumagalli;P. Ruggeri;V. Straniero;M. Pallavicini
2014
Abstract
Specifications for cetyltrimethylammonium (CTA) naproxenate (naprocet), the active ingredient of pharmaceutical liquid preparations used as antiseptic−antinflammatory detergents, fix severe limits to the presence of residual inorganic counteranion deriving from the starting CTA salt. A new simple procedure, which avoids ionic exchange chromatography and utilizes CTAHSO4 in place of CTABr and CTACl, exploits the quantitative precipitation of K2SO4 from methanol to yield naprocet in line with such specification requirements.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Organic process Res. Dev 2014 18 976.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
253.8 kB
Formato
Adobe PDF
|
253.8 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
