Specifications for cetyltrimethylammonium (CTA) naproxenate (naprocet), the active ingredient of pharmaceutical liquid preparations used as antiseptic−antinflammatory detergents, fix severe limits to the presence of residual inorganic counteranion deriving from the starting CTA salt. A new simple procedure, which avoids ionic exchange chromatography and utilizes CTAHSO4 in place of CTABr and CTACl, exploits the quantitative precipitation of K2SO4 from methanol to yield naprocet in line with such specification requirements.

Simple process for the preparation of cetyltrimethylammonium naproxenate (naprocet) / C. Bolchi, E. Valoti, L. Fumagalli, P. Ruggeri, V. Straniero, M. Pallavicini. - In: ORGANIC PROCESS RESEARCH & DEVELOPMENT. - ISSN 1083-6160. - 18:8(2014 Aug), pp. 976-979.

Simple process for the preparation of cetyltrimethylammonium naproxenate (naprocet)

C. Bolchi;E. Valoti;L. Fumagalli;P. Ruggeri;V. Straniero;M. Pallavicini
2014-08

Abstract

Specifications for cetyltrimethylammonium (CTA) naproxenate (naprocet), the active ingredient of pharmaceutical liquid preparations used as antiseptic−antinflammatory detergents, fix severe limits to the presence of residual inorganic counteranion deriving from the starting CTA salt. A new simple procedure, which avoids ionic exchange chromatography and utilizes CTAHSO4 in place of CTABr and CTACl, exploits the quantitative precipitation of K2SO4 from methanol to yield naprocet in line with such specification requirements.
Settore CHIM/08 - Chimica Farmaceutica
Settore CHIM/06 - Chimica Organica
ORGANIC PROCESS RESEARCH & DEVELOPMENT
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/238779
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