The prevalence of exertional hypoxemia in unselected patients with COPD is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) upregulation through the hypoxia-inducible factor-1 pathway. We aimed to assess the prevalence and the annual probability to develop exertional hypoxemia in stable COPD. We also hypothesized that increased ADM might be associated with exertional hypoxemia and envisioned that adding ADM to clinical variables might improve its prediction in COPD.
Exertional Hypoxemia in Stable COPD Is Common and Predicted by Circulating Proadrenomedullin / D. Stolz, W. Boersma, F. Blasi, R. Louis, B. Milenkovic, K. Kostikas, J.G. Aerts, G. Rohde, A. Lacoma, J. Rakic, L. Boeck, P. Castellotti, A. Scherr, A. Marin, S. Hertel, S. Giersdorf, A. Torres, T. Welte, M. Tamm. - In: CHEST. - ISSN 0012-3692. - 146:2(2014 Aug 01), pp. 328-338.
Exertional Hypoxemia in Stable COPD Is Common and Predicted by Circulating Proadrenomedullin
F. Blasi;P. Castellotti;
2014
Abstract
The prevalence of exertional hypoxemia in unselected patients with COPD is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) upregulation through the hypoxia-inducible factor-1 pathway. We aimed to assess the prevalence and the annual probability to develop exertional hypoxemia in stable COPD. We also hypothesized that increased ADM might be associated with exertional hypoxemia and envisioned that adding ADM to clinical variables might improve its prediction in COPD.
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