The prevalence of exertional hypoxemia in unselected patients with COPD is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) upregulation through the hypoxia-inducible factor-1 pathway. We aimed to assess the prevalence and the annual probability to develop exertional hypoxemia in stable COPD. We also hypothesized that increased ADM might be associated with exertional hypoxemia and envisioned that adding ADM to clinical variables might improve its prediction in COPD.
|Titolo:||Exertional Hypoxemia in Stable COPD Is Common and Predicted by Circulating Proadrenomedullin|
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie dell'Apparato Respiratorio|
|Data di pubblicazione:||1-ago-2014|
|Digital Object Identifier (DOI):||10.1378/chest.13-1967|
|Appare nelle tipologie:||01 - Articolo su periodico|