We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLL
Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia / D. Soligo, M. Motta, C. Borsotti, A. Ibatici, A. Cortelezzi, G. Lambertenghi Deliliers. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 89:7(2004), pp. 885-886.
Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia
D. SoligoPrimo
;A. CortelezziPenultimo
;G. Lambertenghi DeliliersUltimo
2004
Abstract
We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLLFile | Dimensione | Formato | |
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