We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLL

Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia / D. Soligo, M. Motta, C. Borsotti, A. Ibatici, A. Cortelezzi, G. Lambertenghi Deliliers. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 89:7(2004), pp. 885-886.

Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia

D. Soligo
Primo
;
A. Cortelezzi
Penultimo
;
G. Lambertenghi Deliliers
Ultimo
2004

Abstract

We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLL
Allogeneic; Chronic lymphocytic leukemia; Reduced-intensity; Transplantation
Settore MED/15 - Malattie del Sangue
2004
http://www.haematologica.org/journal/2004/890885.pdf
Article (author)
File in questo prodotto:
File Dimensione Formato  
885.full.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 231.07 kB
Formato Adobe PDF
231.07 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/23820
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 4
  • ???jsp.display-item.citation.isi??? ND
social impact