Postoperative atrial fibrillation (AF) is a well-known complication occurring after thoracic surgery. B-type natriuretic peptide has recently been investigated as a predictive marker of postoperative AF after cardiac surgery. The aim of this study was to evaluate a definite cut-off for N-terminal pro-B type natriuretic peptide (NT-proBNP) in predicting postoperative AF in lung cancer patients. NT-proBNP was determined before and after surgery in 400 patients. Cardiac function was monitored by continuous postoperative ECG and clinical cardiological evaluation. AF occurred in 18% of the patients. Receiver operating characteristic curve analyses identified a cut-off of 182.3ng l -1 as the one with the highest sensitivity and specificity. Perioperative increased levels of NT-proBNP seem to predict postoperative AF in patients undergoing thoracic surgery, and a single cut-off of 182.3ng l -1 can be used to select high-risk patients who could receive preventive therapy, leading to a considerable decrease in the total costs associated with the management of this complication.
Atrial fibrillation after thoracic surgery for lung cancer : use of a single cut-off value of N-terminal pro-B type natriuretic peptide to identify patients at risk / M. Salvatici, D. Cardinale, L. Spaggiari, F. Veglia, C.C. Tedesco, P. Solli, C.M. Cipolla, L. Zorzino, R. Passerini, D. Riggio, M.C. Cassatella, M.T. Sandri. - In: BIOMARKERS. - ISSN 1354-750X. - 15:3(2010 May), pp. 259-265.
|Titolo:||Atrial fibrillation after thoracic surgery for lung cancer : use of a single cut-off value of N-terminal pro-B type natriuretic peptide to identify patients at risk|
CARDINALE, DANIELA MARIA (Secondo)
|Parole Chiave:||Atrial fibrillation; Lung cancer disease; Natriuretic peptides; NT-proBNP; Thoracic surgery|
|Settore Scientifico Disciplinare:||Settore MED/21 - Chirurgia Toracica|
|Data di pubblicazione:||mag-2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/13547500903509351|
|Appare nelle tipologie:||01 - Articolo su periodico|