The drug named defibrotide (DFT) has been studied for many years. It has been shown to possess many activities: profibrinolytic, antithrombotic-thrombolytic, antiischemic (heart, liver, kidney, skin, brain), antishock, antiatherosclerotic, antirejection and anti-angiogenic. The previously displayed activities, as antithrombotic, profibrinolytic and anti-inflammatory, suggested its use in vascular disorders, as in the treatment of peripheral obliterative arterial disease and in thrombophlebitis. Some years after, the use of DFT in hepatic veno-occlusive disease has been also proposed. Even if DFT was considered for long time a multi-target drug, now it could be considered on the whole as a drug able to protect endothelium against activation. The present work reviews the more important experimental and clinical studies performed to detect DFT effects. © 2013 The Authors.

Defibrotide : properties and clinical use of an old/new drug [Recensione] / R. Pescador, L. Capuzzi, M. Mantovani, A. Fulgenzi, M.E. Ferrero. - In: VASCULAR PHARMACOLOGY. - ISSN 1537-1891. - 59:1-2(2013), pp. 1-10. [10.1016/j.vph.2013.05.001]

Defibrotide : properties and clinical use of an old/new drug

A. Fulgenzi
Penultimo
;
M.E. Ferrero
Ultimo
2013

Abstract

The drug named defibrotide (DFT) has been studied for many years. It has been shown to possess many activities: profibrinolytic, antithrombotic-thrombolytic, antiischemic (heart, liver, kidney, skin, brain), antishock, antiatherosclerotic, antirejection and anti-angiogenic. The previously displayed activities, as antithrombotic, profibrinolytic and anti-inflammatory, suggested its use in vascular disorders, as in the treatment of peripheral obliterative arterial disease and in thrombophlebitis. Some years after, the use of DFT in hepatic veno-occlusive disease has been also proposed. Even if DFT was considered for long time a multi-target drug, now it could be considered on the whole as a drug able to protect endothelium against activation. The present work reviews the more important experimental and clinical studies performed to detect DFT effects. © 2013 The Authors.
Defibrotide ; Endothelial activation ; Inflammation ; Venous occlusive disease
Settore MED/04 - Patologia Generale
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/236802
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