Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed as farnesyltransferase (FTase) inhibitors (FTIs) by replacing AA with o-aryl or o-heteroaryl substituted p-hydroxy- or p-aminobenzoic acid, while maintaining the replacement of C with 1,4-benzodioxan-2-ylmethyl or 2-amino-4-thiazolylacetyl residue as in previous CAAX mimetics. Both FTase inhibition and antiproliferative effect were showed by two thiazole derivatives, namely those with 1-naphthyl (10 and 10a) or 3-furanyl (15 and 15a) in the central spacer, and by the benzodioxane derivative with 2-thienyl (6 and 6a) in the same position. Accumulation of unprenylated RAS was demonstrated in cells incubated with 15a. Consistently with FTIs literature, such results delineate the biaryl scaffold not only as a spacer but also as a sensible area of these mimetic molecules, where modifications at the branching aromatic ring are not indifferent and should be matter of further investigation.

Farnesyltransferase inhibitors : CAAX mimetics based on different biaryl scaffolds / V. Straniero, M. Pallavicini, G. Chiodini, P. Ruggeri, L. Fumagalli, C. Bolchi, A. Corsini, N. Ferri, C. Ricci, E. Valoti. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 24:13(2014 Jul 01), pp. 2924-2927. [10.1016/j.bmcl.2014.04.078]

Farnesyltransferase inhibitors : CAAX mimetics based on different biaryl scaffolds

V. Straniero;M. Pallavicini;G. Chiodini;P. Ruggeri;L. Fumagalli;C. Bolchi;A. Corsini;N. Ferri;C. Ricci;E. Valoti
2014-07-01

Abstract

Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed as farnesyltransferase (FTase) inhibitors (FTIs) by replacing AA with o-aryl or o-heteroaryl substituted p-hydroxy- or p-aminobenzoic acid, while maintaining the replacement of C with 1,4-benzodioxan-2-ylmethyl or 2-amino-4-thiazolylacetyl residue as in previous CAAX mimetics. Both FTase inhibition and antiproliferative effect were showed by two thiazole derivatives, namely those with 1-naphthyl (10 and 10a) or 3-furanyl (15 and 15a) in the central spacer, and by the benzodioxane derivative with 2-thienyl (6 and 6a) in the same position. Accumulation of unprenylated RAS was demonstrated in cells incubated with 15a. Consistently with FTIs literature, such results delineate the biaryl scaffold not only as a spacer but also as a sensible area of these mimetic molecules, where modifications at the branching aromatic ring are not indifferent and should be matter of further investigation.
FTase inhibitor; RAS protein; Mimetic; Benzodioxane; 2-Aminothiazole
Settore CHIM/08 - Chimica Farmaceutica
Settore BIO/14 - Farmacologia
30-apr-2014
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/236308
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