Chlorpromazine is a well-known antipsychotic agent that binds with a variety of receptors in the central nervous system. To date, chlorpromazine has never been associated with onset of hearing disorders and tinnitus. We report on an unexpected suspect adverse reaction to chlorpromazine that occurred in a 12-year-old boy, affected by severe generalized anxiety disorder. After treatment with chlorpromazine, the patient experienced an enhanced sensitivity to sounds accompanied by perception of noises of the buzzing or ringing type. This clinical case is of great clinical interest as chlorpromazine is not currently included among potentially ototoxic drugs.

A case of tinnitus induced by chlorpromazine in a pediatric patient / C. Carnovale, P. Pellegrino, S. Beretta, G.V. Zuccotti, V. Perrone, S. Antoniazzi, M. Pozzi, E. Clementi, S. Radice. - In: JOURNAL OF PHARMACOLOGY AND PHARMACOTHERAPEUTICS. - ISSN 0976-500X. - 5:2(2014 Jun), pp. 163-165. [10.4103/0976-500X.130110]

A case of tinnitus induced by chlorpromazine in a pediatric patient

C. Carnovale;G.V. Zuccotti;E. Clementi
Penultimo
;
S. Radice
Ultimo
2014

Abstract

Chlorpromazine is a well-known antipsychotic agent that binds with a variety of receptors in the central nervous system. To date, chlorpromazine has never been associated with onset of hearing disorders and tinnitus. We report on an unexpected suspect adverse reaction to chlorpromazine that occurred in a 12-year-old boy, affected by severe generalized anxiety disorder. After treatment with chlorpromazine, the patient experienced an enhanced sensitivity to sounds accompanied by perception of noises of the buzzing or ringing type. This clinical case is of great clinical interest as chlorpromazine is not currently included among potentially ototoxic drugs.
adverse drug reaction; chlorpromazine; tinnitus
Settore MED/38 - Pediatria Generale e Specialistica
Settore BIO/14 - Farmacologia
giu-2014
Article (author)
File in questo prodotto:
File Dimensione Formato  
CarnovaleRadice_JournPharmacolPharmacoth_Tinnitus_2014.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 460.45 kB
Formato Adobe PDF
460.45 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/236183
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 6
  • ???jsp.display-item.citation.isi??? ND
social impact