The very high general infection rate (IRI) observed in our Geriatric Intensive Rehabilitation Center (GIRC) led us to investigate whether patient supplementation with essential amino acids (EAAs), modulators of immuno-competence, could reduce IRI. Eighty elderly patients admitted to our GIRC (n=40; age 79.5 ± 7.71; male/female 14/26) or placebo (n=40; age 82.13 ± 6.15; male/female 13/27) were allocated to an 8 g/day oral EAAs group and were surveyed for infections (>48 h from admission) over the first month of their hospital stay. The IRI was 67% for the entire population of patients, 82.5% (33/40 patients) in the placebo group and 52% (21/40 patients) in the EAA group (p<0.02). When patients were divided into infection group (IG) and without-infection group (WIG), independently of post randomization allocation, the WIG had higher levels of serum albumin (p<0.001), blood hemoglobin (Hb) concentration (p=0.01), dietary protein (p=0.008) calorie intakes (p=0.05) but lower serum C-reactive protein (CRP) (p<0.001). The factor of CRP>0.8 mg/dl and Hb ≤ 12 in females, ≤13 in males was associated 4 times and 3.6 times risk of infection, respectively, by sex. EAAs supplementation may lower the risk of infection by 30% in the rehabilitative elderly population. CRP and blood hemoglobin levels can be considered risk markers of future infection.
Effects of oral amino acid supplementation on long-term-care-acquired infections in elderly patients / R. Aquilani, G. C. Zuccarelli, F. S. Dioguardi, P. Baiardi, A. Frustaglia, C. Rutili, E. Comi, M. Catani, P. Iadarola, S. Viglio, A. Barbieri, L. D'Agostino, M. Verri, E. Pasini, F. Boschi. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - 52:3(2011 May), pp. e123-e128.
|Titolo:||Effects of oral amino acid supplementation on long-term-care-acquired infections in elderly patients|
|Parole Chiave:||Essential amino acids; Immunocompetence; Infection of elderly|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||mag-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.archger.2010.09.005|
|Appare nelle tipologie:||01 - Articolo su periodico|