A radioimmunoassay for serum procollagen III aminopeptide (sPIIIP) was proposed recently for monitoring hepatic fibroplasia in patients with various inflammatory hepatic lesions. To determine whether sPIIIP also can detect fibroplasia in noninflammatory liver disorders, we measured this index in 16 patients with idiopathic hemochromatosis (IHC) at various stages of the disease and iron overload. Interestingly, we found normal levels of sPIIIP in 12 out of 16 patients examined (75%), despite clear histologic features of fibrosis or cirrhosis. The levels of sPIIIP exhibited no relationship to any of the clinical, laboratory, or histologic parameters of the disease. Thus, unlike other types of cirrhosis, in which sPIIIP is increased, the liver disease in IHC may be a fibrotic process unrelated to type III collagen stimulation. Accordingly, the determination of sPIIIP in these patients is of no value for monitoring the fibrosis associated with the liver disease.
Serum marker of type III procollagen in patients with idiopathic hemochromatosis and its relationship to hepatic fibrosis / M. Colombo, G. Annoni, M.F. Donato, S. Fargion, C. Tiribelli, N. Dioguardi. - In: AMERICAN JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0002-9173. - 80:4(1983 Oct), pp. 499-502.
|Titolo:||Serum marker of type III procollagen in patients with idiopathic hemochromatosis and its relationship to hepatic fibrosis|
|Parole Chiave:||Adult ; Female ; Hemochromatosis ; Humans ; Liver ; Liver Cirrhosis ; Male ; Middle Aged ; Procollagen ; Radioimmunoassay|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||ott-1983|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/ajcp/80.4.499|
|Appare nelle tipologie:||01 - Articolo su periodico|