The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment.

Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging / S. Casarotto, S. Määttä, S. Herukka, A. Pigorini, M. Napolitani, O. Gosseries, E. Niskanen, M. Könönen, E. Mervaala, M. Rosanova, H. Soininen, M. Massimini. - In: NEUROREPORT. - ISSN 0959-4965. - 22:12(2011 Aug 24), pp. 592-597. [10.1097/WNR.0b013e328349433a]

Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging

S. Casarotto
Primo
;
A. Pigorini;M. Napolitani;M. Rosanova;M. Massimini
2011-08-24

Abstract

The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment.
aging; Alzheimer; cortical excitability; electroencephalography; transcranial magnetic stimulation
Settore BIO/09 - Fisiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/235274
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