Twenty-eight children with, β-thalassaemia major aged between 11 and 48 months were given intensive transfusions. Serum iron, transferrin saturation, serum ferritin, non-transferrin iron, and subcutaneous desferrioxamine-induced urinary iron excretion were measured. The results showed that even children with a limited number of transfusions had severe iron overload as indicated, in particular, by the raised serum ferritin levels and the high excretion rates after subcutaneous infusion of desferrioxamine. The desferrioxamine test was useful, even in very young children, in assessing response to chelation therapy thus enabling such treatment to be started early to prevent harm from iron overload.
Early iron overload in beta-thalassaemia major : when to start chelation therapy? / S. Fargion, M.T. Taddei, V. Gabutti, A. Piga, A. Di Palma, L. Capra, G. Fontanelli, A. Avanzini. - In: ARCHIVES OF DISEASE IN CHILDHOOD. - ISSN 0003-9888. - 57:12(1982 Dec), pp. 929-933.
|Titolo:||Early iron overload in beta-thalassaemia major : when to start chelation therapy?|
|Parole Chiave:||Blood Transfusion ; Child, Preschool ; Deferoxamine ; Hemochromatosis ; Humans ; Infant ; Iron ; Thalassemia|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||dic-1982|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1136/adc.57.12.929|
|Appare nelle tipologie:||01 - Articolo su periodico|