Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Knowledge of the use, methods of application, and adverse effects of hyaluronidases is essential for the aesthetic practitioner. Therefore, we performed an extensive review of the available literature from 1928 to 2011 and compared the different enzymes available, recording each author's indications regarding usage and side effects. © 2013 The American Society for Aesthetic Plastic Surgery, Inc.

The role of hyaluronidase in the treatment of complications from hyaluronic acid dermal fillers / M. Cavallini, R. Gazzola, M. Metalla, L. Vaienti. - In: AESTHETIC SURGERY JOURNAL. - ISSN 1090-820X. - 33:8(2013 Nov 01), pp. 1167-1174.

The role of hyaluronidase in the treatment of complications from hyaluronic acid dermal fillers

R. Gazzola;L. Vaienti
2013-11-01

Abstract

Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Knowledge of the use, methods of application, and adverse effects of hyaluronidases is essential for the aesthetic practitioner. Therefore, we performed an extensive review of the available literature from 1928 to 2011 and compared the different enzymes available, recording each author's indications regarding usage and side effects. © 2013 The American Society for Aesthetic Plastic Surgery, Inc.
dermatological agent; hyaluronic acid; hyaluronic acid filler injection; hyaluronidase; unclassified drug, angioneurotic edema; delayed hypersensitivity; dermatology; drug clearance; drug diffusion; drug eruption; drug half life; drug hypersensitivity; drug induced disease; drug mechanism; drug safety; echography; enzyme activity; human; injection site edema; injection site erythema; injection site pain; injection site pruritus; injection site reaction; nose septum reconstruction; plastic surgery; priority journal; review; skin manifestation; urticaria
Settore MED/19 - Chirurgia Plastica
AESTHETIC SURGERY JOURNAL
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/234786
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