Aim: The purpose of this study was to illustrate a correlation between the occurrence of dental anomalies of number, shape, position, changes in dento-facial growth and immunosuppressive therapy in children undergoing bone marrow transplantation in the first year of life. Materials and methods: 5 children were treated with bone marrow transplantation in the first year of life, immunosuppressants to control rejection reactions. These young patients were suffering from severe combined immunodeficiency (SCID). The SCID is a group of primary immunodeficiencies, usually hereditary, characterized by a lack of numerical and functional T and B lymphocytes. Results: The SCID was diagnosed by: finding early after the birth of B and T lymphopenia; deficiency of humoral immunity and cellular growth arrest, fungal infections, viral and opportunistic microorganisms. In addition to the immune defect, in about 50% of patients, is observed dento-skeletal abnormalities Conclusions: An approach as positive as possible from the early stages of therapy, will help the patient, to be followed for a long period of life. The importance of the collaboration between different branches of Medicine and the Dentist assumes particular value in these cases and highlights the need for the multidisciplinary approach as the only possible solution of restitutio ad integrum of stomatognathic function.
Scopi del lavoro: Lo scopo del lavoro è stato illustrare una correlazione tra l’insorgenza di anomalie dentali di numero, forma, posizione, alterazioni della crescita dento-facciale e la terapia immunosoppressiva in bambini nel primo anno di vita. Materiali e metodi: Sono stati considerati 5 bambini con trapianto di midollo osseo subito nel primo anno di vita, in terapia con gli immunosoppressori per controllare le reazioni di rigetto. Questi piccoli pazienti erano affetti da immunodeficienze combinate gravi (SCID,) Le SCID, sono un gruppo di immunodeficienze primitive, di solito ereditarie, caratterizzate da un difetto numerico e funzionale dei linfociti T e B Risultati: La SCID viene diagnosticata da: riscontro precoce dopo la nascita di linfopenia B e T; deficit dell’immunità umorale e cellulare; arresto della crescita; infezioni fungine, virali e da microrganismi opportunisti. Oltre al difetto immunitario, in circa il 50% dei pazienti si osservano malocclusioni dento-scheletriche. Conclusioni: Un approccio il più positivo possibile sin dalle prime fasi di terapia, sarà di aiuto al paziente, che dovrà essere seguito per un lungo periodo della vita. L’importanza assunta dalla collaborazione tra diverse branche dell’Odontoiatria e della Medicina assume in questi casi particolare valore e mette in risalto la necessità dell’approccio multidisciplinare quale unica possibile soluzione della restitutio ad integrum della funzione stomatognatica.
Alterazioni della crescita dentofacciale in soggetti sottoposti a terapia immunosoppressiva nel primo anno di vita - Dento-facial growth alterations in the subjects undergone to immunosuppressive therapy at first year of life / U. Garagiola, P. Cressoni, S. Pozzi Taubert, F. Picchioni, R. Soldo, C. Bellintani. ((Intervento presentato al 24. convegno CONGRESSO INTERNATIONALE SIDO tenutosi a Firenze nel 2012.
Alterazioni della crescita dentofacciale in soggetti sottoposti a terapia immunosoppressiva nel primo anno di vita - Dento-facial growth alterations in the subjects undergone to immunosuppressive therapy at first year of life
U. GaragiolaPrimo
;
2012
Abstract
Aim: The purpose of this study was to illustrate a correlation between the occurrence of dental anomalies of number, shape, position, changes in dento-facial growth and immunosuppressive therapy in children undergoing bone marrow transplantation in the first year of life. Materials and methods: 5 children were treated with bone marrow transplantation in the first year of life, immunosuppressants to control rejection reactions. These young patients were suffering from severe combined immunodeficiency (SCID). The SCID is a group of primary immunodeficiencies, usually hereditary, characterized by a lack of numerical and functional T and B lymphocytes. Results: The SCID was diagnosed by: finding early after the birth of B and T lymphopenia; deficiency of humoral immunity and cellular growth arrest, fungal infections, viral and opportunistic microorganisms. In addition to the immune defect, in about 50% of patients, is observed dento-skeletal abnormalities Conclusions: An approach as positive as possible from the early stages of therapy, will help the patient, to be followed for a long period of life. The importance of the collaboration between different branches of Medicine and the Dentist assumes particular value in these cases and highlights the need for the multidisciplinary approach as the only possible solution of restitutio ad integrum of stomatognathic function.Pubblicazioni consigliate
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