Purpose : To compare the antibiotic prophylaxis based on quinolone administered orally with a combination of cephalosporin administered periprostatically and a fluoroquinolone orally, in terms of post-prostate bioptic infectious complication rates in those men undergoing transrectal ultrasound-guided prostate biopsy (TRUS gpb). Methods : In a prospective, randomized, double-blind study, 150 consecutive patients were randomized to receive 10 ml lidocaine 1 % in Group A and ceftriaxone 1 g diluted in a solution of 10 ml of lidocaine 1 % in Group B, before TRUS gpb. All signed the informed consent. The men were asked to grade the pain using a ten points visual analogue scale close after TRUS gpb. In a telephone interview at 3 and 6 days, they were asked about early and late complications, assessing rectal bleeding, urinary retection, fewer, haematuria, urethral bleeding and hematospermia. Results : Of the 150 men enrolled, 135, 70 in Groups A and 65 in Group B, completed the study. Four men (5.7 %) in Group A developed sepsis after TRUS gpb requiring hospital admission and intravenous antibiotic treatment, while none in Group B. Escherichia coli was the only organism isolated. The mean pain score was 2.76 ± 1.69 and 1.73 ± 1.26 for Group A and B, respectively (p = 0.08). Complications, evaluated at 3 and 6 days after the procedure through a telephone interview, were similar in both Groups. Conclusions : The antibiotic prophylaxis based on the combination of ceftriaxone administered periprostatically and ciprofloxacin orally is able to offer a best control on infections caused by fluoroquinolone-resistant E. coli.
Cephalosporins periprostatic injection: are really effective on infections following prostate biopsy? / G. Pace, L. Carmignani, C. Marenghi, G. Mombelli, G. Bozzini. - In: INTERNATIONAL UROLOGY AND NEPHROLOGY. - ISSN 0301-1623. - 44:4(2012 Aug), pp. 1065-1070.
|Titolo:||Cephalosporins periprostatic injection: are really effective on infections following prostate biopsy?|
CARMIGNANI, LUCA FABIO (Secondo)
BOZZINI, GIORGIO (Ultimo)
|Parole Chiave:||Administration, Oral; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Biopsy, Needle; Cephalosporins; Double-Blind Method; Follow-Up Studies; Humans; Injections; Male; Middle Aged; Prospective Studies; Prostate; Prostatitis; Sepsis; Treatment Outcome|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
|Data di pubblicazione:||ago-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s11255-012-0160-x|
|Appare nelle tipologie:||01 - Articolo su periodico|