The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing the reversal of stalled and terminal replication forks. Hu et al. now show that the ATR pathway targets the Dna2 nuclease to process stalled forks and counteract fork reversal.
Dna2 offers support for stalled forks / M.S. Lai, M. Foiani. - In: CELL. - ISSN 0092-8674. - 149:6(2012 Jun 08), pp. 1181-1183.
Dna2 offers support for stalled forks
M. Foiani
2012
Abstract
The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing the reversal of stalled and terminal replication forks. Hu et al. now show that the ATR pathway targets the Dna2 nuclease to process stalled forks and counteract fork reversal.
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