To assess Body Mass Index (BMI) as a predictor of progression to dementia, 228 subjects with mild cognitive impairment (MCI) were followed-up for 2,4±1,6 years. Dementia occurred in 117 subjects. Cumulative incidence (CI) of dementia was significantly higher (p=0.006) among MCI who were underweight (BMI<20 kg/m2) at baseline (CI=81.0%) as compared to MCI who were normal weight (CI=53.2%) or overweight/obese (BMI>25 kg/m2) (CI=42.9%). Being underweight significantly increased the risk of dementia (HR 2.4; 95% CI 1.2-5.1) but not that of Alzheimer’s disease (HR 2.3; 95% CI 0.9-5.6). BMI assessment may help improving prognostic accuracy of MCI in clinical practice.
INFLUENZA DELL'INDICE DI MASSA CORPOREA SUL RISCHIO DI PROGRESSIONE DA MILD COGNITIVE IMPAIRMENT A DEMENZA / A. Rossi ; relatore: F. Clerici ; tutor: C. Mariani ; coordinatore: R. Weinstein. UNIVERSITA' DEGLI STUDI DI MILANO, 2014 Mar 10. 26. ciclo, Anno Accademico 2013. [10.13130/rossi-annalia_phd2014-03-10].
INFLUENZA DELL'INDICE DI MASSA CORPOREA SUL RISCHIO DI PROGRESSIONE DA MILD COGNITIVE IMPAIRMENT A DEMENZA
A. Rossi
2014
Abstract
To assess Body Mass Index (BMI) as a predictor of progression to dementia, 228 subjects with mild cognitive impairment (MCI) were followed-up for 2,4±1,6 years. Dementia occurred in 117 subjects. Cumulative incidence (CI) of dementia was significantly higher (p=0.006) among MCI who were underweight (BMI<20 kg/m2) at baseline (CI=81.0%) as compared to MCI who were normal weight (CI=53.2%) or overweight/obese (BMI>25 kg/m2) (CI=42.9%). Being underweight significantly increased the risk of dementia (HR 2.4; 95% CI 1.2-5.1) but not that of Alzheimer’s disease (HR 2.3; 95% CI 0.9-5.6). BMI assessment may help improving prognostic accuracy of MCI in clinical practice.File | Dimensione | Formato | |
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