Invasive meningococcal disease is a severe clinical condition which most commonly presents as sepsis or meningitis and can cause death or major long-term sequelae. Neisseria meningitidis serogroup B (MenB) is one of the major causes of invasive meningococcal disease. The availability of the complete genome sequence of a MenB strain led to the development of a four-component vaccine specific for this pathogen (4CMenB), which has been tested in animals and humans. 4CMenB is shown to be immunogenic in pediatric subjects and is effective in vitro for most of the different MenB strains. However, several problems must still be adequately solved before the vaccine can be universally recommended. Further studies are needed to evaluate the vaccine's coverage over time, duration of protection, the immunogenicity of a simplified administration scheme, and the real incidence of severe rare adverse events. In addition, the effect of 4CMenB on MenB carriers and its cost-effectiveness ratio are needed to more completely describe the characteristics of this vaccine.

Vaccine profile of 4CMenB : a four-component Neisseria meningitidis serogroup B vaccine / S. Esposito, N. Principi. - In: EXPERT REVIEW OF VACCINES. - ISSN 1476-0584. - 13:2(2014 Feb), pp. 193-202.

Vaccine profile of 4CMenB : a four-component Neisseria meningitidis serogroup B vaccine

S. Esposito
Primo
;
N. Principi
Ultimo
2014

Abstract

Invasive meningococcal disease is a severe clinical condition which most commonly presents as sepsis or meningitis and can cause death or major long-term sequelae. Neisseria meningitidis serogroup B (MenB) is one of the major causes of invasive meningococcal disease. The availability of the complete genome sequence of a MenB strain led to the development of a four-component vaccine specific for this pathogen (4CMenB), which has been tested in animals and humans. 4CMenB is shown to be immunogenic in pediatric subjects and is effective in vitro for most of the different MenB strains. However, several problems must still be adequately solved before the vaccine can be universally recommended. Further studies are needed to evaluate the vaccine's coverage over time, duration of protection, the immunogenicity of a simplified administration scheme, and the real incidence of severe rare adverse events. In addition, the effect of 4CMenB on MenB carriers and its cost-effectiveness ratio are needed to more completely describe the characteristics of this vaccine.
Settore MED/38 - Pediatria Generale e Specialistica
feb-2014
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/232922
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 16
social impact