Background: Exposures to several dusts and fibers (DFs) have been established or suggested as etiologic factors for lung cancer. Methods: To investigate lung cancer risk in relation to exposure to DFs, we identified 540 pathologically-diagnosed lung cancer cases and 582 controls from the 1993-1998 autopsy records of the 88 hospitals of Leningrad Province, Russia. Lifetime job-specific exposure measurements were available for 15 organic, 15 man-made and 28 natural-inorganic agents. Results: In male workers, increased risks were found for linen dust (OR= 3.68, 95% CI 1.00-13.6, adjusted for age, smoking and residence), and unspecified DFs (OR= 1.44, 95% CI 1.07-1.94). Small non-significant excess risks were observed for quartz dust (OR= 1.27; 95% CI 0.83-1.93) and man-made vitreous fibers (MMVFs) (OR= 1.82, 95% CI 0.88-3.75). In female subjects, risks were non-significantly associated with paper dust (OR= 1.77, 95% CI 0.74-4.20), and unspecified DFs (OR= 1.52, 95% CI 0.77-3.03). Conclusions: The study showed increased lung cancer risk for selected categories of DFs.
|Titolo:||Risk of lung cancer from exposure to dusts and fibers in Leningrad Province, Russia|
BACCARELLI, ANDREA (Primo)
|Parole Chiave:||Glass wool; Linen dust; Man-made vitreous fibers; Occupation; Paper dust; Particles; Quartz|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Data di pubblicazione:||giu-2006|
|Digital Object Identifier (DOI):||10.1002/ajim.20316|
|Appare nelle tipologie:||01 - Articolo su periodico|