The novel non-conventional metallodrug [(η6-p-cymene)2Ru2mitoxantronato]Cl2 (1) exhibits redox activity, DNA intercalation ability, cathepsin B and D inhibition and in vitro antitumor activity able to circumvent cisplatin resistance. Moreover, 1 can be successfully incorporated into MIL100(Fe) as a proof of concept of the feasibility of metal–organic frameworks as carriers of non-conventional drugs.

Biophysical characterisation, antitumor activity and MOF encapsulation of a half-sandwich ruthenium(ii) mitoxantronato system / S. Rojas, E. Quartapelle Procopio, F.J. Carmona, M.A. Romero, J.A.R. Navarro, E. Barea. - In: JOURNAL OF MATERIALS CHEMISTRY. B. - ISSN 2050-750X. - 2:17(2014 Mar 18), pp. 2473-2477.

Biophysical characterisation, antitumor activity and MOF encapsulation of a half-sandwich ruthenium(ii) mitoxantronato system

E. Quartapelle Procopio
Secondo
;
2014-03-18

Abstract

The novel non-conventional metallodrug [(η6-p-cymene)2Ru2mitoxantronato]Cl2 (1) exhibits redox activity, DNA intercalation ability, cathepsin B and D inhibition and in vitro antitumor activity able to circumvent cisplatin resistance. Moreover, 1 can be successfully incorporated into MIL100(Fe) as a proof of concept of the feasibility of metal–organic frameworks as carriers of non-conventional drugs.
metal-organic frameworks; anticancer metallodrugs; drug-delivery; cathepsin-B; complexes; inhibition; agents
Settore CHIM/03 - Chimica Generale e Inorganica
1-nov-2013
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/232762
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