We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response.
Modulation of DNA repair genes induced by TLR9 agonists : a strategy to eliminate "altered" cells? / M. Sommariva, L. De Cecco, E. Tagliabue, A. Balsari. - In: ONCOIMMUNOLOGY. - ISSN 2162-4011. - 1:2(2012 Mar 01), pp. 258-259. [10.4161/onci.1.2.18343]
Modulation of DNA repair genes induced by TLR9 agonists : a strategy to eliminate "altered" cells?
M. SommarivaPrimo
;A. Balsari
2012
Abstract
We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response.
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