Background: Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction. Patients and methods: A pooled analysis of a history of pancreatitis and risk of pancreatic cancer was carried out considering the time interval between diagnoses and potential modification by covariates. Adjusted pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from 10 case-control studies (5048 cases of ductal pancreatic adenocarcinoma and 10 947 controls) taking part in the International Pancreatic Cancer Case-Control Consortium (PanC4). Results: The association between pancreatitis and pancreatic cancer was nearly three-fold at intervals of >2 years between diagnoses (OR: 2.71, 95% CI: 1.96-3.74) and much stronger at intervals of ≤2 years (OR: 13.56, 95% CI: 8.72-21.90) probably reflecting a combination of reverse causation and antecedent misdiagnosis of pancreas cancer as pancreatitis. The younger (<65 years) pancreatic cancer cases showed stronger associations with previous (>2 years) pancreatitis (OR: 3.91, 95% CI: 2.53-6.04) than the older (≥65 years) cases (OR: 1.68, 95% CI: 1.02-2.76; P value for interaction: 0.006). Conclusions: Despite a moderately strong association between pancreatitis (diagnosed before >2 years) and pancreatic cancer, the population attributable fraction was estimated at 1.34% (95% CI: 0.612-2.07%), suggesting that a relatively small proportion of pancreatic cancer might be avoided if pancreatitis could be prevented.
Pancreatitis and pancreatic cancer risk : a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4) / E.J. Duell, E. Lucenteforte, S.H. Olson, P.M. Bracci, D. Li, H.A. Risch, D.T. Silverman, B.T. Ji, S. Gallinger, E.A. Holly, E.H. Fontham, P. Maisonneuve, H.B. Bueno-de-Mesquita, P. Ghadirian, R.C. Kurtz, E. Ludwig, H. Yu, A.B. Lowenfels, D. Seminara, G.M. Petersen, C. La Vecchia, P. Boffetta. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 23:11(2012 Nov), pp. mds140.2964-mds140.2970.
|Titolo:||Pancreatitis and pancreatic cancer risk : a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)|
LUCENTEFORTE, ERSILIA (Secondo)
|Parole Chiave:||Case-control studies; Pancreatic cancer; Pancreatitis; Pooled analysis; Risk factors|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||nov-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/annonc/mds140|
|Appare nelle tipologie:||01 - Articolo su periodico|