The mode of action of zosteric acid at a cellular and molecular level was explored. In order to find main molecular determinants of the anti-biofilm activity in zosteric acid structure, chemical modifications of the sulfate phenolic ester and the carboxylic acid moieties were performed. The anti-biofilm activity of the modified antifoulants was verified and compared with the activity of zosteric acid through a quantitative biofilm assay using fluorochrome-labelled cells in hydrophobic microplate wells. Toxicity of the modified antifoulants was also tested to exclude a biocide effect. The tests were performed against E. coli. Information about the part of molecule responsible for the anti-biofilm activity was obtained.
Natural compounds for controlling microbial adhesion and biofilm formation / C. Cattò. ((Intervento presentato al 8. convegno Workshop. Doctorate in Chemistry, Biochemistry and Ecology of Plant Protection Products and Xenobiotics tenutosi a Milano nel 2013.
Natural compounds for controlling microbial adhesion and biofilm formation
C. CattòPrimo
2013
Abstract
The mode of action of zosteric acid at a cellular and molecular level was explored. In order to find main molecular determinants of the anti-biofilm activity in zosteric acid structure, chemical modifications of the sulfate phenolic ester and the carboxylic acid moieties were performed. The anti-biofilm activity of the modified antifoulants was verified and compared with the activity of zosteric acid through a quantitative biofilm assay using fluorochrome-labelled cells in hydrophobic microplate wells. Toxicity of the modified antifoulants was also tested to exclude a biocide effect. The tests were performed against E. coli. Information about the part of molecule responsible for the anti-biofilm activity was obtained.Pubblicazioni consigliate
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