CONDENSED ABSTRACT Aldosterone to renin ratio (ARR) was calculated in supine and standing position in 88 patients with essential hypertension while on their usual antihypertensive treatment measuring renin as plasma renin activity (PRA) and as plasma renin concentration (PRC) using a direct assay. For comparison ARR was evaluated also in ten patients with aldosterone producing adenoma (APA). We found that values of ARR calculated with the two methods (ARRP and ARRD) were highly significantly correlated and similar irrespective of body posture. Moreover assuming as thresholds of normalcy those recommended by the Endocrine Society Guidelines, i.e. 30 for ARRP and 3.7 for ARRD, we found 13 and 18 false positive ARRP respectively in the supine and standing position whereas, in the corresponding positions, there were 0 and 4 false positives with ARRD. Among patients with APA we found only one false negative ARRD. Thus the specificity of ARRD is greater than that of ARRP and excellent, particularly in the recumbent position, in spite of on going antihypertensive treatment.

Measurement of plasma renin concentration instead of plasma renin activity decreases the positive aldosterone-to-renin ratio tests in treated patients with essential hypertension / C. Lonati, N. Bassani, A. Gritti, E. Biganzoli, A. Morganti. - In: JOURNAL OF HYPERTENSION. - ISSN 0263-6352. - 32:3(2014 Mar), pp. 627-634. [10.1097/HJH.0000000000000076]

Measurement of plasma renin concentration instead of plasma renin activity decreases the positive aldosterone-to-renin ratio tests in treated patients with essential hypertension

C. Lonati
Primo
;
A. Gritti;E. Biganzoli;A. Morganti
Ultimo
2014

Abstract

CONDENSED ABSTRACT Aldosterone to renin ratio (ARR) was calculated in supine and standing position in 88 patients with essential hypertension while on their usual antihypertensive treatment measuring renin as plasma renin activity (PRA) and as plasma renin concentration (PRC) using a direct assay. For comparison ARR was evaluated also in ten patients with aldosterone producing adenoma (APA). We found that values of ARR calculated with the two methods (ARRP and ARRD) were highly significantly correlated and similar irrespective of body posture. Moreover assuming as thresholds of normalcy those recommended by the Endocrine Society Guidelines, i.e. 30 for ARRP and 3.7 for ARRD, we found 13 and 18 false positive ARRP respectively in the supine and standing position whereas, in the corresponding positions, there were 0 and 4 false positives with ARRD. Among patients with APA we found only one false negative ARRD. Thus the specificity of ARRD is greater than that of ARRP and excellent, particularly in the recumbent position, in spite of on going antihypertensive treatment.
plasma renin activity ; plasma renin concentration ; aldosterone to renin ratio ; primary hyperaldosteronism
Settore MED/09 - Medicina Interna
mar-2014
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/231960
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 26
social impact