MicroRNAs (miRNAs) are small non-coding RNAs that act as posttranscriptional regulators of gene expression. In the past few years growing evidence has supported a key role for miRNAs in central nervous system development and homeostasis [1]. More recently,dysregulation in miRNA expres- sion have been observed in different neuropsychiatric disorders,including major depression, and a few studies have suggested a role for miRNAs in the action of mood stabilizers and antidepressants [2]. Based on this, aim of the present study was to evaluate the effects of treatment for 3 and 21 days with agomelatine, a new antidepressant with a unique receptor profile as MT1/MT2 receptors agonist and 5-HT2C receptor antagonist [3], on the miRNome expression profile in rat hippocampus
Early and time-dependent modulation of rat hippocampal miRNome during treatment with agomelatine / D. Tardito, M. Seguini, D. Corrada, I. Merelli, A. Mallei, L. Milanesi, G. Racagni, M. Popoli. - In: EUROPEAN NEUROPSYCHOPHARMACOLOGY. - ISSN 0924-977X. - 23:Suppl. 2(2013 Sep), pp. S312-S312. ((Intervento presentato al 26. convegno ECNP Congress tenutosi a Barcelona nel 2013 [10.1016/S0924-977X(13)70489-9].
Early and time-dependent modulation of rat hippocampal miRNome during treatment with agomelatine
D. Tardito;M. Seguini;A. Mallei;G. Racagni;M. Popoli
2013
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that act as posttranscriptional regulators of gene expression. In the past few years growing evidence has supported a key role for miRNAs in central nervous system development and homeostasis [1]. More recently,dysregulation in miRNA expres- sion have been observed in different neuropsychiatric disorders,including major depression, and a few studies have suggested a role for miRNAs in the action of mood stabilizers and antidepressants [2]. Based on this, aim of the present study was to evaluate the effects of treatment for 3 and 21 days with agomelatine, a new antidepressant with a unique receptor profile as MT1/MT2 receptors agonist and 5-HT2C receptor antagonist [3], on the miRNome expression profile in rat hippocampusPubblicazioni consigliate
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