Background: The incidence rates of esophageal and gastric cardia adenocarcinoma (EGCA) have increased over recent years in several countries, and overweight/obesity has been suggested to play a major role in these trends. In fact, higher body mass index (BMI) has been positively associated with EGCA in several studies. Material and methods: We conducted a meta-analysis of case-control and cohort studies on the BMI and EGCA updated to March 2011. We estimated overall relative risks (RRs) and 95% confidence intervals (CI) for BMI between 25 and 30 and BMI ≥ 30 kg/m2, when compared with normo-weight subjects, using random-effects models. Results: We identified 22 studies, including almost 8000 EGCA cases. The overall RR was 1.71 (95% CI 1.50-1.96) for BMI between 25 and 30, and was 2.34 (95% CI 1.95-2.81) for BMI ≥ 30 kg/m2. The continuous RR for an increment of 5 kg/m2 of BMI was 1.11 (95% CI 1.09-1.14). The association was stronger for esophageal adenocarcinoma (RR for BMI ≥ 30 kg/m2 = 2.73, 95% CI 2.16-3.46) than for gastric cardia adenocarcinoma (RR for BMI ≥ 30 kg/m2 = 1.93, 95% CI 1.52-2.45). No substantial differences emerged across strata of sex and geographic areas. Conclusion: Overweight and obesity are strongly related to EGCA, particularly to espophageal adenocarcinoma.

A meta-analysis of body mass index and esophageal and gastric cardia adenocarcinoma / F. Turati, I. Tramacere, C. La Vecchia, E. Negri. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 24:3(2013 Mar), pp. mds244.609-mds244.617. [10.1093/annonc/mds244]

A meta-analysis of body mass index and esophageal and gastric cardia adenocarcinoma

F. Turati;I. Tramacere;C. La Vecchia;E. Negri
2013-03

Abstract

Background: The incidence rates of esophageal and gastric cardia adenocarcinoma (EGCA) have increased over recent years in several countries, and overweight/obesity has been suggested to play a major role in these trends. In fact, higher body mass index (BMI) has been positively associated with EGCA in several studies. Material and methods: We conducted a meta-analysis of case-control and cohort studies on the BMI and EGCA updated to March 2011. We estimated overall relative risks (RRs) and 95% confidence intervals (CI) for BMI between 25 and 30 and BMI ≥ 30 kg/m2, when compared with normo-weight subjects, using random-effects models. Results: We identified 22 studies, including almost 8000 EGCA cases. The overall RR was 1.71 (95% CI 1.50-1.96) for BMI between 25 and 30, and was 2.34 (95% CI 1.95-2.81) for BMI ≥ 30 kg/m2. The continuous RR for an increment of 5 kg/m2 of BMI was 1.11 (95% CI 1.09-1.14). The association was stronger for esophageal adenocarcinoma (RR for BMI ≥ 30 kg/m2 = 2.73, 95% CI 2.16-3.46) than for gastric cardia adenocarcinoma (RR for BMI ≥ 30 kg/m2 = 1.93, 95% CI 1.52-2.45). No substantial differences emerged across strata of sex and geographic areas. Conclusion: Overweight and obesity are strongly related to EGCA, particularly to espophageal adenocarcinoma.
Body mass index; Esophageal and gastric cardia adenocarcinoma; Meta-analysis; Obesity; Overweight.
Settore MED/01 - Statistica Medica
ANNALS OF ONCOLOGY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/231686
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