Disclosed are compounds of formula (I): wherein one of A and B is the group:(II) wherein R1 is selected from H and OCH3, and the other is the group:(III) wherein R2 is selected from H, OH, NO2, NH2; R3 is selected from OH and NH2; 15 the salts, enantiomers and diastereoisomers thereof; with the exclusion of the following compounds: 3,4-cis-3-hydroxy-4-(3-nitro-4-methoxyphenyl)-1-(3,4,5- trimethoxyphenyl)azetidin-2-one; 3,4-cis-4-(3-amino-4-methoxyphenyl)-3-hydroxy-1-(3,4,5-20 trimethoxyphenyl)-azetidin-2-one; for use as antitumor agents.

1,4-DIARYL-2-AZETIDINONES WITH ANTITUMORAL ACTIVITY / R. Pagliarin, F. Orsini, G. Montano, F. Tripodi, P. Coccetti, P.A. Fusi.

1,4-DIARYL-2-AZETIDINONES WITH ANTITUMORAL ACTIVITY

R. Pagliarin;F. Orsini;G. Montano;
2013

Abstract

Disclosed are compounds of formula (I): wherein one of A and B is the group:(II) wherein R1 is selected from H and OCH3, and the other is the group:(III) wherein R2 is selected from H, OH, NO2, NH2; R3 is selected from OH and NH2; 15 the salts, enantiomers and diastereoisomers thereof; with the exclusion of the following compounds: 3,4-cis-3-hydroxy-4-(3-nitro-4-methoxyphenyl)-1-(3,4,5- trimethoxyphenyl)azetidin-2-one; 3,4-cis-4-(3-amino-4-methoxyphenyl)-3-hydroxy-1-(3,4,5-20 trimethoxyphenyl)-azetidin-2-one; for use as antitumor agents.
Università degli Studi di Milano
Università degli Studi di Milano Bicocca
WO2013/017548 A1
MI2011A001463
Settore CHIM/06 - Chimica Organica
Settore BIO/10 - Biochimica
1,4-DIARYL-2-AZETIDINONES WITH ANTITUMORAL ACTIVITY / R. Pagliarin, F. Orsini, G. Montano, F. Tripodi, P. Coccetti, P.A. Fusi.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/231419
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